Archive - BioBoyScout

Nobody Gets to Wait

Arrowhead proved a shot can silence a gene in the human brain. The proof was expensive to produce and it is free to read.

Nov 1 • BioBoyScout

October 2026

Nobody Else Has a Key

Everyone wants a way into the brain without a spinal needle. Arrowhead is the first to show what subcutaneous RNAi can do in a person.

Oct 26 • BioBoyScout

The Check Has Not Been Played

My Forced Move papers named two events: a gate the thesis had to survive and a check that starts the cascade. Only one has happened.

Oct 21 • BioBoyScout

The Liver Got Paid

Small trials, enormous moves. The liver was rewarded and punished in double digits. Arrowhead reached the brain and closed up 0.41 percent.

Oct 18 • BioBoyScout

The Bishop Moved

Arrowhead silenced a gene in the human brain with a shot under the skin. The number is 73 percent. The interesting parts are when, and where.

Oct 14 • BioBoyScout

Ninety-Eight Percent of Nothing

Two tau drugs produced impressive numbers. The field read both of them wrong. What to watch on October 14.

Oct 11 • BioBoyScout

The FDA built a faster review lane four years ago and almost nobody used it. Arrowhead just walked in, and kept the voucher it bought for speed.

Oct 7 • BioBoyScout

New siRNA companies are signing billion-dollar deals. The published playbook gets them into the liver. Past it, they have to earn their way.

Oct 4 • BioBoyScout

September 2026

The Long Diagonal

Arrowhead's brain drug is aimed at Alzheimer's. The webinar agenda hints the fastest road there may run through rarer diseases.

Sep 29 • BioBoyScout

Nobody Sells for Seven Percent

Goldman Sachs gets almost everything right about Arrowhead. Then its theoretical acquisition value lands below the stock's own fifty-day average.

Sep 24 • BioBoyScout

Opening Preparation

Arrowhead put eighteen drugs into human trials between 2017 and 2023, and has kept going since. That is one every four months, and it is not because…

Sep 23 • BioBoyScout

Arrowhead has RNAi drugs in six tissues, five by a shot under the skin. Nobody else comes close. This is about why everyone else stayed put, and about…

Sep 21 • BioBoyScout

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